ñ-tocopherol (ñ-T) out of the 8 major analogues of vitamin E has been a particular focus because of its strong antioxidant properties. ñ-T is enriched in the plasma of humans and higher animals 10-100-fold to an average of 23.2 üM. In Vitamin E isomers, ñ-T is a fat-soluble vitamin, where as it phosphate form, ñ-tocopherol phosphate (ñ-TP) is naturally occurring water-soluble form. ñ-T has strong antioxidant activity, the chromanol OH group in ñ-TP is phosphorylated so that it has no antioxidant activity. ñ-TP acts as a detergent forming a barrier which might inhibit the transfer of free radicals from one polyunsaturated fatty acid. ñ-TP more efficiently modulated atherosclerotic and inflammatory events than ñ-T by reducing THP-1 cell proliferation and expression of the CD36 scavenger receptor. ñ-TP and ñ-T act as lipid mediators modulating signal transduction and gene expression.
Michael Eskin NA
https://www.omicsonline.org/open-access/vitamin-e-and-the-role-of-watersoluble-tocopheryl-phosphate-vms.1000e123.php?aid=24737
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