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Physical, Thermal and Spectral Properties of Biofield Energy Treated 2,4-Dihydroxybenzophenone
Study background: 2,4-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents. The objective of this study was to investigate the influence of biofield energy treatment on the physical, thermal and spectral properties of DHBP. The study was performed in two groups (control and treated).. Read More
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Introduction: Spirulina is a unicellular blue-green alga rich in vitamins, minerals, pigments, proteins, polysaccharides, which indicates a high potential use in anti-aging cosmetic products as well as for skin protection. Preliminary studies showed antioxidant potential, immediate benefits on the skin microrelief and hydration .. Read More
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The study on interaction and complexation of drug molecules with other drugs and various metal ions is an important field of research in the chemical, biochemical, medicinal and pharmacological point of views. The biological action of the drug-metal complexes may affect stability and usual activities of drugs through changing ph.. Read More
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The aim of this study was to evaluate the clinical efficacy of an oral supplementation based on hydrolyzed collagen and vitamins in the improvement of aged skin conditions using biophysical and skin imaging techniques. In this doubleblind, placebo-controlled trials, 60 woman aged between 40-60 years were randomized to receive th.. Read More
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Insulin is a polypeptide hormone produced by the β cells present in Islets of Langerhans of the pancreas. Either failure to produce (type 1 diabetes) or utilize insulin (type 2 diabetes) causes diabetes mellitus. Insulin administration is used to treat type 1 diabetes. The common route for insulin administration is via subc.. Read More
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In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo G.. Read More
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Simple HPLC Method for the Determination of Caspofungin in Human Plasma
Antifungal caspofungin (CPFG) was approved for the treatment of febrile neutropenia (FN) as the empiric treatment. However, the relationship between pharmacokinetic properties of CPFG and its clinical effects in patients with FN has not been fully established yet. Thus, in the present study, we tried to establish the simple and .. Read More
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Novel Approaches to Enhance, Bioavailability of Solid Dosage Forms
Solid dosage forms, which were being used since ancient days, have been made modifications in terms of their drug delivery systems. As there are many adverse effects caused by solid dosage forms, recent advanced techniques were developed to minimize the adverse effects. These techniques are encapsulating the drug with matrix, an.. Read More
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Background: HER 2 Metastatic Breast Cancer (MBC) is usually considered incurable. Prognosis has considerably improved over the past two decades with the advent of new therapies such as monoclonal antibodies interfering with the Her2/neu receptor. Case presentation: We present a case of 61 year old woman with Her2 positive MBC w.. Read More
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Serum MSM Concentrations Following One Month of MSM Treatment in Healthy Men
Introduction: Methylsulfonylmethane (MSM) is a commonly used dietary supplement for the alleviation of joint and muscle pain. It is known primarily for its anti-inflammatory and antioxidant properties. While it is believed to have excellent bioavailability, little is known about its serum concentrations following chronic ingesti.. Read More
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Background: Diabetes Mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. Half century ago hydrochlorothiazide has been associated with a diagnosis of diabetes in hypertension treatment containing hydrochlorothiazide during long term therapy. This explained by association between gluc.. Read More
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Background: Tardive dyskinesia (TD) is a severe neurologic adverse reaction occurring with long-term use of metoclopramide. Aim: To examine all reported legal cases involving metoclopramide-induced TD prior to June 16, 2014 in an effort to inform physicians and practitioners of the current legal risks associated with the prescri.. Read More
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Objective: The aims of this study were to evaluate the student’s knowledge, awareness and the reasons behind self medication in two higher education institutes in Al Qassim region of Saudi Arabia. Subjects and method: This pre-validated anonymous questionnaire was used in English and Arabic language that contains both open.. Read More
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In the U.S., there are approximately 9 million adults with osteoporosis (OP) and an additional 43 million at-risk. By 2030, this number is expected to increase to 68 million adults. The economic impact is estimated to be $23 billion by 2025. Current drug therapies either decrease bone resorption (e.g., bisphosphonates) or stimul.. Read More
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Supportive Treatment of Pressure Ulcers with Dietary Supplementation
Pressure ulcers remain a major health problem in immobilized patients, both hospitalized and staying at nursing or private homes. Malnutrition is a significant risk factor for their development and dietary supplementation is a potentially valuable method of supportive treatment. However, clinical data showing specific efficacy o.. Read More
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Objective: Organic Cation Transporter 1 (OCT1) plays a key role in the disposition of metformin in hepatocytes; a recent non-clinical study reported that the peroxisome-proliferator activated receptor γ agonist pioglitazone increased the expression of Slc22a1 (Oct1) by 3.1-fold as well as its transporting function. We ther.. Read More
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This study aims to evaluate the protective effects of Quercetin and Ursodeoxycholic acid (UDCA), as compared to standard agent N-acetylcysteine (NAC), on hepatic ischemia-reperfusion (IR)-induced injury in rats. Briefly, rats were divided into five groups, namely sham control, IR control, NAC, Quercetin and UDCA groups. Assessed.. Read More
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Oral administration of Glibenclamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas. Gastro intestinal absorption of Glibenclamide in man is uniform, rapid and essentially complete having peak plasma concentration 1-3 hours after single oral dose and half-life of elimination th.. Read More
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Stem Cell Approaches for Treatment of Neurodegenerative Diseases
Neurodegenerative diseases are devastating age-related disorders severely affecting the patient, caregivers, and enormously increasing the financial burden of the nation. Despite decades of hard work both in laboratory and clinic, the effective treatment specifically designed for a patient is still far from reach. Stem cell ther.. Read More
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Skin Reactions Associated to Phenytoin Administration: Multifactorial Cause
Purpose: Cutaneous reactions can be associated with phenytoin administration. Such reactions can be explained by the formation of reactive species (arene oxide and quinones) capable of interacting covalently with cell macromolecules during phenytoin metabolism. Enzymes involved in reactive species detoxification are polimorphica.. Read More
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