|"An adaptive measure to prevent blood loss during delivery when the placenta is separated from the uterus. The hypercoagulative state is enhanced in preeclampsia and this is observed by multiple studies through the upregulation of proteins including fibrinogen beta chain (2/2 studies), fibrinogen gamma chain (2/2 studies), and kininogen (2/2 studies), all involved in fibrin clot formation during the coagulation cascade. These results support previous targeted studies that detected elevated fibrinogen levels inserum of women with preeclampsia. Fibronectin is detected as upregulated by four studies and is only expressed by activated platelets as a feedback to limit excessive response.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."