Adverse drug reactions (ADRs) are a leading cause of morbidity and mortality. A major contributing factor to ADRs is Drug-Drug Interactions (DDIs), which often results from pharmacodynamic (PD) and pharmacokinetics (PK) changes due to co-administration of one or more therapeutic agents. Clearly, the chances of such interactions are higher in therapeutic areas requiring administration of a cocktail therapy such as that in cancer, HIV, epilepsy and CNS disorders. Pankaj B. Desai, Pharmacokinetics bases of adverse drug-drug interactions.
Last date updated on June, 2021