Alzheimer¬ôs disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-√é¬≤ protein (A√é¬≤)fibrils, respectively. Numerous reports suggest that A√é¬≤ aggregation,namely the formation of A√é¬≤ oligomers, is an early event precedingother pathological changes in AD. A√é¬≤ is physiologically generatedfrom the cleavage of amyloid precursor protein by √é¬≤- and √é¬≥-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
Innovations are new idea, device or process. Innovations are the application of better solutions that meet new requirements, inarticulated needs or existing market needs. It is proficient through more effective products, processes, services, technologies, or new ideas that are readily available to markets, governments and society. Innovations are something original and novel, as a significant, new that √Ę¬Ä¬úbreaks into√Ę¬Ä¬Ě the market or society.
Last date updated on July, 2021