|Alzheimerâs disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-Î² protein (AÎ²)fibrils, respectively. Numerous reports suggest that AÎ² aggregation,namely the formation of AÎ² oligomers, is an early event precedingother pathological changes in AD. AÎ² is physiologically generatedfrom the cleavage of amyloid precursor protein by Î²- and Î³-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.