|Accrued evidence suggesting that hypovitaminosis D acts as a risk factor for developing ParkinsonÂ™s disease(PD) remains controversial. Herein we evaluated existing results, and outline several biological mechanisms by which the hypovitaminosis D-PD relationship may occur. We performed a meta-analysis, using data obtained froma search of PubMed from July 2002 to July 2012, for studies reporting serum vitamin D levels in PD and controlpatients.We found that in comparison to healthy individuals, those with PD had lower levels of serum vitamin D. Furthermore, we explore a number of potential associated biological mechanisms, including the actions of reactivenitrogen species (RNS), glutathione (GSH), and glial-derived neurotrophic factor (GDNF) in the brain.
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