Alzheimer's disease develops differently for every individual, there are many common symptoms. Early symptoms are often mistakenly thought to be 'age-related' concerns, or manifestations of stress. In the early stages, the most common symptom is difficulty in remembering recent events, known as short term memory loss. These changes result in a cerebral atrophy with cognitive and neuropsychiatric symptoms. The vast majority of cases of Alzheimer's disease are late-onset cases over 60 years. However, there are early forms of AD (EOAD) in which the genetic load is high and associated with mutations in APP, PSEN1, and PSEN2 genes (encoding amyloid precursor protein, presenilin 1, and presenilin 2, respectively).
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Last date updated on November, 2020