|The urgent need for a more effective approach to treatment of dementia, regardless of underlying pathology, is obvious. Current medications demonstrate only limited benefit; experimental drugs to date not only failed to slow progression, but, most recently, as in the case of semagacestat, worsened clinical measures of cognition. The prevalence of Alzheimer Disease and other dementias is growing rapidly, with estimates of a crippling
number of affected persons by the year 2030 as the Baby Boomers and Generation X members reach high
dementia probability ages. Current medical interventions to treat dementing disorders have been disappointing
and suggest that amyloid clearing agents are likely not the answer.
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