Metals like arsenic, cadmium, chromium, lead, nickel, and others are a major source of oxidative stress. Substantial data suggest that oxidative stress is involved in the development of breast cancer. The alteration of trace metals in breast tissue, the level of oxidative stress and antioxidant status in the blood of breast cancer patients and to investigate the relationship between these parameters. Metal carcinogenicity and genotoxicity are based on three main mechanisms, namely, oxidative stress, DNA repair modulation, and disturbances of signal transduction pathways. Disruption of metal ion homeostasis may lead to oxidative stress, a state where increased formation of ROS overwhelms body antioxidant protection and subsequently induces DNA damage, lipid peroxidation, protein modification and carcinogenesis. using MDA as a marker of oxidative stress, there has been a growing interest in studying the role played by lipid peroxidation in cancer progression.
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Last date updated on July, 2014