Alzheimer disease (AD) is the most common cause of senile dementia that progressively robs the victims of their memory, mental faculties and basic activities of independent living. Although specific genetic mutations have been identified that directly cause the disease, these cases are rare. Rather, interplay between genetic, metabolic and environmental factors seems to trigger the onset of pathological changes. These variants appear to be fully penetrant and result in Alzheimer disease with an early onset, in most cases before the age of 60 years.
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Last date updated on September, 2020