The eponym of Alzheimers disease has been around for more than one century from 1910. Its diagnosis varies: from senile dementia to senium praecox (for both pre-senile and senile dementia) to Mild Cognitive Impairment (MCI) leading to AD as the most feared form of dementia. Dementia can be tested and diagnosed as the effects of brain atrophy; it manifests in a cluster of behavioral alterations; the causes can be vascular or non-vascular in origin. Thus, dementia is neither a disease nor equivalent to AD. Plaques and tangles should be called Fischer disease (FD) which gradually causes brain atrophy to result progressively from simple dementia to presbyophrenia in a dichotomy as suggested by Fischer.
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Last date updated on July, 2014