The apoptotic resistance against oxidative stress led by c-Cbl in MEFs to the effect of c-Cbl in human malignant cells, it was important to analyse c-Cbl impact in a human cancer cell line. c-Cbl protects cells against the oxidative stress that is often sustained by cancer cells, noting that c-Cbl is highly expressed in these malignant cells. a correlation between c-Cbl and oxidative stress association of strong oxidative stress and high c-Cbl expression in malignant cells (six c-Cbl positive among nine APE1 positive, no c-Cbl positive associated with APE1 negative). c-Cbl over-expression protects human malignant cells against apoptosis and particularly upon oxidative stress. The level of endonuclease expression related to oxidative stress in the LNCaP cell line subjected to transient silencing of c-Cbl by monitoring the anti-APE1/REF1 signal.
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Last date updated on July, 2014