There is strong evidence that coronary heart disease (CHD) is associated with polymorphisms in several genes connected with dyslipidemia, impaired blood coagulation, inflammation and other factors of the CHD. This suggests the existence of genes that coordinate the activity of risk alleles. Circadian genes are of special interest in this respect; however, the extent of their relationship with coronary atherosclerosis is not known. In particular, polymorphism in CLOCK gene is associated with cholesterol, in PER1 with hemostasis (e.g. fibrinogen) etc. Because circadian genes are also responsible for synchronization of metabolic processes including lipid metabolism, they may be involved into CHD development in a direct (biorhythmicity disturbances such as time shifts or disruption in cycles of atherogenic mechanisms) and indirect way (by affecting various components of atherosclerotic process).
A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.
Last date updated on July, 2014