alexa Anti-malarial Activity of New Emodin Derivatives against Plasmodium falciparum Chloroquine Resistant Strain

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Anti-malarial Activity of New Emodin Derivatives against Plasmodium falciparum Chloroquine Resistant Strain

Emodin (1) is the major bioactive compound of several herb species, which belongs to anthraquinone class of compound. As a part of our drug discovery program, large quantities of emodin (1) was isolated from the roots of Rheum emodi and a library of novel emodin derivatives 2–24 were prepared to evaluate their in-vitro antimalarial activity, among them, compound 17,18 and 20 showed potent antimalarial activity against chloroquine resistant strain PfK1 with the IC50 of 2.28, 2.49 and 2.48 μM respectively with a high safety index.

Citation: Pandeti S, Gunjan S, Paidipelli S, Tripathi R, Tadigoppula N (2014) Anti-malarial Activity of New Emodin Derivatives against Plasmodium falciparum Chloroquine Resistant Strain. Nat Prod Chem Res 2:150. doi: 10.4172/2329-6836.1000150

 
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