alexa Prevalence of Cardiovascular Risk Factors on Different Phases of Diabetic Nephropathy in Comparison to Type 1 Diabetes Recipients who had Undergone Simultaneous Pancreas Kidney Transplant

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Prevalence of Cardiovascular Risk Factors on Different Phases of Diabetic Nephropathy in Comparison to Type 1 Diabetes Recipients who had Undergone Simultaneous Pancreas Kidney Transplant

The aims of this study were to evaluate the relationship between different phases of diabetic nephropathy and the beneficial effect of successful simultaneous pancreas-kidney transplant (SPKT) on the prevalence of cardiovascular risk factors (CVRF). We analyzed 210 type 1 diabetic patients (age>18 years and diabetes duration ≥ 10 years). Patients were divided into five groups: normo, micro, macroalbuminuric, end stage renal disease (ESRD), and SPKT. The following CVRF, besides diabetes, were analyzed: blood pressure, waist circumference, HDL cholesterol and triglycerides. The prevalence of ≥ 2 CVRF increased from normoalbuminuric to end stage renal disease group: 20.7%, 43.4%, 53.6%, 71.4% (p<0.001), respectively. In the SPKT group, this prevalence was 18.5%. Two or more CVRF were positively associated with female gender (OR=2.5; p=0.008) and with diabetes duration over 15 years (OR=2.6; p=0.023). The SPKT was a protective factor (OR=0.3; p=0.047), and ESRD was a risk factor (OR=5.2, p=0.014) for the presence of CVRF. In conclusion, the severity of diabetic nephropathy was associated with a higher prevalence of two or more CVRF in type 1 diabetes mellitus. After SPKT, that prevalence was similar to normoalbuminuric patients.

Citation: Neves MDF, Rangel EB, Sá JR, Dib SA (2013) Prevalence of Cardiovascular Risk Factors on Different Phases of Diabetic Nephropathy in Comparison to Type 1 Diabetes Recipients who had Undergone Simultaneous Pancreas Kidney Transplant. J Diabetes Metab S9:002.

 
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