Ranitidine is used in peptic ulcer therapy and available as several brands in the market which makes it difficult to select the safe, effective and economic one. The aim of this study is to establish similarity among the different brands of ranitidine HCl tablets available in local market of Karachi, Pakistan. Four different brands of (150 mg) were selected for the study. Six quality control parameters: weight variation test, hardness test, thickness, friability, disintegration test and dissolution test were carried out specified by USP. Result revealed that all brands comply within limits for hardness, weight variation, thickness, friability, disintegration and dissolution. Disintegration time for all brands was within 15 minutes complying with the USP commendation. All brands showed Q-value more than 80% within 45 minutes. The present findings suggest that almost all the brands of ranitidine HCl that are available in Karachi meet the USP specification for quality control analysis and are interchangeable.