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Use of non-human primates to establish animal models is essential for some special human diseases, such as Acquired Immunodeficiency Syndromes (AIDS). Non-human primates have played various roles in the development of licensed vaccines against human pathogens like anthrax, hepatitis A, hepatitis B, polio, rabies, and yellow fever. Knowledge on the biology of the immune system of primates may be the key factors determining how much the monkey experiments can really “tell us” about such human diseases in question or the efficacy of the vaccines or vaccine concept tested. Excellent results in human AIDS vaccine trials using rhesus macaques have been published, however, not all of them have lead to successful clinical trials on humans.
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