Transplantation is well accepted therapy for end organ failure. However it has its own disadvantages in the form of life-long immunosuppression to prevent rejection of the grafted organ. It is a well-known fact that graft survival improves significantly with better HLA-matched donor. However it is not possible to get a good matched kidney for all the patients. In addition, even with good matched organs the patients are kept on standard maintenance immunosuppression universally. Attempts to minimize immunosuppression are going on at different centres with some success. We have been using stem cell therapy (SCT) for safe and effective minimization of immunosuppression in living donor renal transplantation (LDRT). Recently T-regulatory cells (T-regs) (CD4+CD25hiFoxP3+), a sub-population of T lymphocytes have been identified for their immumodulatory role in diseases and transplantation. Tregs were formerly known as natural suppressor cells and are involved in shutting down immune responses after successfully eliminating invading organisms. Absence of Tregs was found to be associated with autoimmune disorders. Studies were carried out in transplantation to correlate the levels of Tregs with graft function status. T-regs are believed to be associated with sustained tolerance in solid organ transplantation. However there is no report of in vitro generation of T-regs and then using them in vivo. This study aims to present our initial experience of infusing in vitro generated T-regulatory cells (T-regs) in LDRT.
Trivedi H, Vanikar A, Patel H, Kute V, Dave S (2014) Regulatory T-Cells Support Stem Cell Therapy in Safe Minimization of Immunosuppression in Living Donor Renal Transplantation. J Stem Cell Res Ther 4: 240. doi: 10.4172/2157-7633.1000240