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In the present study, the authors have not performed time-course inflammatory responses to renal ischemia, which may allow us to observe Influx of inflammatory cells, predominantly macrophages, and lymphocytes in the renal arterial clipped kidney in early phase. Also, not analyzed the renal function. It is of interest to further confirm the role of IL-1β in the development of renin-dependent hypertension using IL-1β -/- mice applied to the 2K1C mouse model.
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