Abstract The use of Platelet-Rich-Plasma (PRP) may provide a new and improved treatment option for early Temporomandibular Joint (TMJ) Osteoarthritis (OA). However, there are no studies on its use in TMJ arthritis in the literature. The present study compares 30 early onsets OA patients divided equally into 3 groups who had experienced no pain reduction following conservative and minimally invasive arthrocentesis and arthroscopy treatment. All patients had retrodiscitis and synovitis on arthroscopic examination and were without systemic joint disease, septic, or autoimmune arthritis. Only patients with unilateral TMJ symptoms were included in this study.