Objective: To study the height LDLsd levels and coronary disease relation. Methods: Experimental transversal and retrospective study of sample not probabilistic random. 62 individuals were studied of both sex who did attended a consultation specialized in cardiology at the University Queen Fabiola Clinic of Cordoba city Argentina. The LDLsd are separated using vertical polyacrylamide gradient gel electrophoresis to 3% in non-reducing conditions. The presence of LDLsd was established when identified in the serum LDLsd abnormal band with Rf>0.36. Results: 26 patients have LDLsd elevated and 36 patients with normal LDLsd Rf<0.36). In 36 (58%) patients with normal LDLsd, 27 (75%) of them have not coronary disease and diabetes. A correlation study between factors of risk and coronary disease with a 95% of statically significance resulted that 16 patients with coronary disease had height LDLsd (Rf>0.36) and 7 patients without disease (p<0.001). Conclusion: The research revealed high levels of LDLsd in subjects assessed, by association with coronary disease increased significantly. Patients with normal TGR who had elevated levels of LDLsd had developed coronary artery disease; it confirms to LDLsd as independent of coronary disease risk factor.