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Nephropathy is a chronic micro vascular complication of diabetes. Uncontrolled blood sugar level and high blood pressure are risk factor for the development of nephropathy or End Stage Renal Disease (ESRD). The Renin-Angiotensin-Aldosterone System (RAAS) is a regulator of both blood pressure and kidney functions and is suggested to play an important role in the development of nephropathy in Type 2 Diabetes Mellitus and genes encoding components of the RAAS can be candidate genes for evaluating predisposition for the development of hypertension, cardiovascular disease, ESRD or progression of renal disease in type 2 diabete.
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