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Colorectal cancer (CRC), an age-related disease, is the third most common cancer in the world. Although sporadic CRC, which affects 80-85% of CRC patients, is a multi-step process initiated by APC gene mutation and is becoming increasingly evident that a small sub-population of cells termed cancer stem/stem-like cells (CSCs/CSLCs) plays vital roles in the progression of this malignancy specially the recurrence and drug resistance. This blog explains the genetic and epigenetic changes observed at different stages in the progression of sporadic CRC and also roles of miRNAs that control gene expression and CSCs/CSLCs in regulating proliferation, differentiation, and survival of the colon cancer cells.
Cancer Stem Cells in Colorectal Cancer: Genetic and Epigenetic Changes
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