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Loss of thyroid tissue: Treatment of hyperthyroidism by radioactive destruction of thyroid tissue or surgical removal of thyroid tissue can result in hypothyroidism. Antithyroid antibodies: These may be present in people who have type 1diabetes, lupus, rheumatoid arthritis, chronic hepatitis, or Sjogren's syndrome. These antibodies may cause decreased production of thyroid hormones because of thyroid destruction. Hashimoto's thyroiditis, the most common cause of hypothyroidism in an adult, occurs because of autoimmune destruction of the thyroid results in a decreased production of thyroid hormone and an increased amount of TSH. Congenital defects in the production of thyroid hormone: Hypothyroidism can be present from birth. This is commonly discovered early with nationwide newborn screening for this disease. When one of the steps in thyroid hormone synthesis is defective, the production of thyroid hormone is reduced, with a subsequent increase in TSH. The increased TSH results in a goiter (enlargement of the thyroid gland itself that can be seen as an obvious swelling in the front of the neck). If the metabolic block is severe, thyroid hormone levels are low begining at birth, resulting in mental retardation, goiter, and short stature (hypothyroid cretinsim). Medications: Some medications, particularly lithium (Eskalith, Lithobid), may cause a drug-induced hypothyroidism. You can submit articles in our peer reviewed Journal at http://scitechnol.com/submitmanuscript.php
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