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Concomitant Chemoradiation Therapy (CRT) has become a widely accepted strategy for the primary treatment of locoregionally advanced head and neck squamous cell carcinoma (HNSCC). CRT achieves excellent tumor response rates, while allowing for organ preservation and decreased morbidity compared to surgery. For N1 disease, CRT alone provides sufficient regional control, with no need for subsequent neck dissection unless there is evidence of neck disease following CRT. For N2 or greater disease, however, management has traditionally involved planned neck dissection after CRT, regardless of treatment response.
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