alexa Gaps in our Knowledge of Genetics underlying Familial Cancer

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Gaps in our Knowledge of Genetics underlying Familial Cancer

The gap in understanding that requires immediate attention is the role of genetic variants that fall between the two extremes; moderately penetrant genetic variants that confer 3-fold or greater increase in relative risk. Increased cancer surveillance would be justified in this population, and like the known highly penetrant cancer genes, the molecular pathways identified may play a role in all cancers.

Citation: Neklason DW (2012) Gaps in our Knowledge of Genetics underlying Common Familial Cancer. Genetics S2:e001. 

 
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