alexa sdRNA: siRNA ; An Efficient and Target-gene Specific RNA Interference

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sdRNA: siRNA ; An Efficient and Target-gene Specific RNA Interference

The ability to induce off-target effects on unintended genes is strongly correlated to the thermodynamic stability of the duplex formed between the seed region (positions 2-8 from the 5\' end of the siRNA guide strand) and target mRNA. siRNAs with seven deoxyribonucleotides exclusively in the seed region (sdRNA) may exhibit efficient target-specificity, but off-target effect-reduced RNAi activity.

 

Citation: Ui-Tei K (2012) sdRNA: siRNA with a DNA Seed for an Efficient and Target-gene Specific RNA Interference. Gene Technol 1:102.

 

 
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