Meta Description: Mismatch of the alternative splicing mechanism has been involved in causing various debilitating pediatric diseases. Recent findings pediatric research related to molecular mechanisms provide the foundation for therapeutic innovation of different diseases associated with RNA processing.

 

Mismatch of the alternative splicing mechanism has been involved in causing various debilitating pediatric diseases like retinitis pigmentosa which will cause blindness, leukemia, cystic fibrosis, acute lymphoblastic leukemia in children.

 

Recent findings related to different types of molecular mechanisms like RNA processing and alternative splicing in pediatric research may provide the basic information for therapeutic innovation and to treat diseases associated with aberrant RNA processing. 

 

Advances in the nanotechnology field provide an unique opportunity to selectively deliver appropriately designed antisense oligonucleotides or chimeric molecules for exon specific splicing enhancement to treat refractory leukemia cells by using multifunctional nanoparticles made of biodegradable block copolymers of polyethylene glycol and cationic polycarbonate.