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Parathyroid gland (PTG) involvement by differentiated thyroid cancer (DTC) patients is rare and its influence on disease outcome has been less studied. We aimed to evaluate the frequency and patterns of PTG involvement in DTC patients and to evaluate the influence of PTG infiltration by DTC on treatment outcome in our cohort. Methods: Demographic, clinicopathologic characteristics and treatment outcomes of sixteen patients of PTG involvement were reviewed in a series of consecutive 823 DTC patients treated during July 2001 and December 2012 with thyroidectomy followed by radioactive iodine therapy and radiation therapy. Data regarding the occurrence of locoregional recurrence (LRC) or distant metastasis (DM), disease free survival (DFS) and overall survival (OS) rates were recorded. LRC, DMC, DFS and OS rates were also compared to matched controls (T3, T4a and M1) using the log-rank test. Results: Mean age of cohort was 57.5 years (42.9-72.1) with female gender preponderance (75%). Sixteen cases of DTC with PTG involvement were found among the 823 patients (1.94%).
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