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Thyroid carcinoma is the most common endocrine malignancy and 80% of all thyroid malignancies are papillary thyroid carcinoma . The diagnosis of papillary thyroid carcinoma is based on architectural features combined with nuclear features, including nuclear clearing, overlapping, grooves and pseudoinclusions. It is always challenging in our everyday practice to distinguish folicualr variant papillary thyroid carcinoma (FVPTC), one of the subtypes of PTC, from cellular adenomatous nodules. Nuclear clearing in benign thyroid lesion, such as in Hashimoto’s disease may lead pathologists to misdiagnose papillary thyroid carcinoma. In an unusual condition, it may also be difficult for differentiating papillary hyperplastic nodules from papillary thyroid carcinoma.
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