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Sleep is perhaps the most enigmatic of all behaviors, without any clear known purpose though conserved from fruit flies to rodents to humans. It has long been appreciated that abnormal sleep and mental illness are intimately related, and sleep disruptions are diagnostically relevant across many psychiatric disorders [1]. While we have gained some insight into the neurobiological and molecular underpinnings of sleep [2], there is still a limited understanding of why sleep occurs, what happens when sleep is disrupted, and why sleep changes are linked to nearly all psychiatric disorders. Advances in each of these areas are needed to successfully address sleep abnormalities in humans and begin to identify the potential role of sleep in maintaining mental health.
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