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While only less than 2% of the mammalian genome codes for proteins, tens of thousands of genomic sites are pervasively transcribed and produce non-coding RNAs, including microRNAs, Piwi-interacting RNAs, small interfering RNAs, small nucleolar RNAs and long non-coding RNAs (lncRNAs). lncRNAs play important roles in a variety of biological processes including development, differentiation, metabolism, genome regulation and cancer progression.
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