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Pregnant women, neonates and the elderly are the individuals suffering human listeriosis but also chronic autoimmune, hepatic transplanted and oncologic patients become infected. While no vaccine is available for human listeriosis, this pathogen has increased 5-fold its annual incidence in our country health institutions and, therefore, there is an urgency to develop a safe and wide vaccine that covers the diversity of all human groups at risk of listeriosis. The reasons for this increase in listeriosis referred to the aging of the population and to the significant increase on the half-life of oncological and transplanted patients with the new biological therapies
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