Drug hypersensitivity reactions (DHR) account for approximately 15% of all adverse drug reactions, can be life threatening, require or prolong the period of hospitalization and entail changes in drug prescription. DHR represent an important problem because they may cause significant morbidity, mortality and high costs for public health systems . Drug allergy is defined by the World Allergy Organization as an immunologically mediated reaction that occurs after re-exposure to the offending drug, through mechanisms mediated or not by IgE  that may provoke recurrence upon re-exposure to the drug. The clinical picture of drug hypersensitivity is very heterogeneous and of variable severity. Although hypersensitivity can affect many organ systems, the most common target is the skin.
Citation: Teixeira FM, Vasconcelos LMF, AraÃºjo TS, Genre J, et al. (2013) Association of CD69 and CD 25 Activation Markers on CD4 and CD8 Cells with Skin Tests in Drug Allergy. J Pharmacovigilance 1:111. doi: 10.4172/2329-6887.1000111