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Hypoglycemia in patients with diabetes mellitus is a common occurrence and has been established to negatively impact their quality of life. It may be as a result of the hypoglycemic drug therapy and is usually related to noncompliance issues, such as inadequate food intake. It is also well established that the risk of hypoglycemia among patients with diabetes mellitus is increased with the presence of other comorbidities, as well as concomitant administration of other drug therapy. Drug interactions that increase the risk of hypoglycemia can be through pharmacokinetic mechanisms, such as inhibition of drug metabolism or through pharmacodynamic mechanisms, such as increase β-cell function; the impact of these interactions may require dose adjustments.
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