Mucoadhesive formulations have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. This drug delivery system is suitable for drugs undergoing high first pass metabolism. It improves bioavailability, reduces dosing frequency and thereby minimizes the side effects and also makes the dosage forms more cost effective. In the present study, polysaccharide derived from the fruits of Cordia dichotoma (Family- Boraginaceae) was investigated as a mucoadhesive polymer in oral (Buccal or sublingual) patch formulation. Ramipril, an antihypertensive drug, was selected as a model drug.
Citation: Pawar Harshal A., Jadhav Surekha M. Jadhav Pravin T.,Rachel G. (2014) Development and Evaluation of Mucoadhesive Patch Using a Natural Polysaccharide Isolated from Cordia dichotoma Fruit. J Mol Pharm Org Process Res 2:120. doi: 10.4172/2329-9053.1000120