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Nucleosome-assembly protein-related proteins (NRPs) are multifunctional proteins having histone chaperone [1] and histone phosphatase inhibitor [2] properties and being implicated in root meristem maintenance [1], mitotic regulation [1], chromatinmediated gene silencing [1], genotoxic sensitivity [1] and homologous recombination [3]. The drosophila homologue of plant NRPs, the SET protein, has been shown to accumulate at heat-shock gene loci in response to increased temperature where it co-localized with Ser10-phosphorylated histoneH3 [4]. It was therefore hypothesized that the drosophila SET protein prevents phosphatase2A (PP2A)- mediated histoneH3 dephosphorylation and contributes to chromatin modifications facilitating heat shock protein gene transcription [4].
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