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DNA (cytosine 5-) MethylTransferase 1 (DNMT1) maintains the pre-existing methyl marks onto daughter strands by faithfully copying the methylation pattern from hemimethylated DNA during replication phase. The fundamental role of DNA methylation in cell physiology makes a controlled regulation of DNMT1 necessary. DNMT1 loss and global DNA hypomethylation are correlated with genomic instability in cancer.
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