alexa DNMT1 and Genomic Instability in Cancer

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DNMT1 and Genomic Instability in Cancer

DNA (cytosine 5-) MethylTransferase 1 (DNMT1) maintains the pre-existing methyl marks onto daughter strands by faithfully copying the methylation pattern from hemimethylated DNA during replication phase. The fundamental role of DNA methylation in cell physiology makes a controlled regulation of DNMT1 necessary. DNMT1 loss and global DNA hypomethylation are correlated with genomic instability in cancer.

 

Barra V (2014) DNMT1 and Genomic Instability in Cancer. J Mol Genet Med 8:113. doi: 10.4172/1747-0862.1000113

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