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Both T1DM and T2DM are characterized by the slow progression towards the generation of some specific lesions of the blood vessels affecting both small (microangiopathy) and larger (macroangiopathy) vessels. The “classical” microvascular complications of diabetes are represented by diabetic retinopathy (the main cause of blindness in adults), diabetic renal disease, representing currently the main cause of renal substitution therapy (dialysis or renal transplantation) in developed countries, and diabetic neuropathy. Major epidemiological and interventional studies showed that chronic hyperglycemia is the main contributor to diabetic tissue damage.
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