Since the insertion of antibiotics in human and veterinary medicine, antibiotic resistance problems in bacteria started increasing consistently. This expansion of multi-resistant germs is due to the self-medications and the misuse of medicines. The raising of therapeutic failures due to the emergence of antibiotics multi-resistant germs requires the use of new and effective sources that are cheap and more accessible for our populations. These requirements could therefore be met by pharmacopoeia plants. Thus, Africa's biodiversity represent an important asset in searching new therapeutic approaches against infections caused by multi-resistant bacteria. Many species of plants with therapeutic properties were recorded with pharmacognosia research. The results showed that the ethanol extract of Terminalia superba's bark is effective against the reference E. coli ATCC 25922 strain and possess a wound healing potential. That extract is also very active in vitro against the reference strain of S. aureus ATCC 25923 and its antibacterial effect was noticed in vivo after 15 days of treatment. It will be interesting to test greater concentrations of that extract on infected lesions or to create a formulation from the powder of the bark of Terminalia superba having a thick consistency in order to prolong the action duration of the formulation in contact with the lesions.