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Todd B. Nippoldt, M.D. Generally, there's no hypothyroidism diet. Although claims about hypothyroidism diets abound, there's no evidence that eating or avoiding certain foods will improve thyroid function in people with hypothyroidism. If you have hypothyroidism, take thyroid hormone replacement as directed by your doctor — generally with an empty stomach. It's also important to note that too much dietary fiber can impair the absorption of synthetic thyroid hormone. Certain foods, supplements and medications can have the same effect
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