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Tau is a group of microtubules- associated proteins found in neurofibrillary tangles (NFT) in Alzheimer’s disease (AD) brain. Tau is a phosphoprotein which by phosphorylation, negatively regulates its ability to stimulate microtubule assembly in 1977. Tau was hyperphosphorylated in brain extracts from AD cases and that it may cause the defect in microtubule assembly and self-assembly into paired helical filaments, forming neurofibrillary tangles.
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