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Dexamethasone used for prophylaxis and treatment of PONV may cause perineal pruritus/pain of variable intensity in awake patients. It is more common in female patients. This pain or pruritus can be diminished or even abolished by giving dexamethasone diluted in 50 ml of fluid over five to ten minutes. Another method of abolishing this discomfort is to administer dexamethasone after induction of anaesthesia. The pharmaceutical preparation of non phosphate containing dexamethasone may also be recommended.
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