Behavioral and gene expression studies indicate that the IL-1 system is associated with alcohol drinking behavior. The GABAergic transmission in central nucleus of the amygdala (CeA) is one of the crucial mediators of alcohol addiction. Thus, wehypothesize that the IL-1 system plays an important role in alcohol effects via modulation of CeAGABAergic synapses. It was examined interactions between IL-1 system and ethanol on GABAergic transmission in brain slices containing CeA using intracellular and whole-cell recordings. Superfusion of IL-1β decreased GABAergic transmission, whereas ethanol enhanced it in B6129SF2/J mice.