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Various abnormalities in gastrointestinal structure and function have been described in patients with liver cirrhosis, including altered gastrointestinal motility, intestinal permeability and absorption. While these changes may not be as clinically overt as other common complications of chronic liver disease, they not only influence nutritional status, but can also contribute to clinical complications such as hepatic encephalopathy and spontaneous bacterial peritonitis. Disruption of the gut barrier function has also been implicated in the pathogenesis of liver fibrosis in alcoholic and non-alcoholic fatty liver disease. This review aims to highlight the abnormalities in gastrointestinal function that are commonly observed in patients with chronic liver disease and their impact on the overall outcomes in these patients.
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