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Azathioprine is frequently used in the treatment of Crohn’s disease. A severe side effect is acute pancreatitis, which is specific for Crohn’s disease. Autoantibodies against exocrine pancreas occur in about 30% of Crohn’s disease cases but not in other inflammatory diseases. Pancreatic autoantibody positive Crohn’s disease patients might have a low grade inflammation of the pancreas which may be aggravated by the introduction of azathioprine, resulting in clinically overt acute pancreatitis. Rinse K Weersma et al. hypothesized that the presence of pancreatic autoantibodies in Crohn’s disease patients is associated with the development of azathioprine-induced pancreatitis.
Citation: https://www.omicsonline.org/open-access/are-pancreatic-autoantibodies-associated-with-azathioprineinduced-pancreatitis-in-crohns-disease.pdf?aid=29429
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