A lectin from the plant pathogenic fungus Rhizoctonia bataticola (RBL) has shown unique sugarbinding specificity towards the complex N-glycans, which are known to be expressed in many cancers, including ovarian cancer. Previous studies have demonstrated that RBL exerts cytotoxic effects on human ovarian cancer PA-1 cells. In the present study, we determined the signaling mechanism of RBL-induced cytotoxicity in PA-1 cells upon binding to cell surface receptors and also assessed the anti-tumor activity of RBL in NOD-SCID mice bearing ovarian xenografts.
Citation: Eligar SM, Pujari R, Savanur MA, Nagre NN, Barkeer S, et al. (2013) Rhizoctonia Bataticola Lectin (RBL) Induces Apoptosis in Human Ovarian Cancer PA-1 Cells and Suppresses Tumor Growth In Vivo. J Glycobiol S1:001. doi: 10.4172/2168-958X.S1-001