Meta Description: Thalassemia is an inherited blood disease characterized by inadequate production of haemoglobin globin subunits, ineffective hematopoiesis, and increased hemolysis. Thalassemia is seen as the most frequent monogenic disease in the world.
Thalassemia is an inherited blood disease characterized by inadequate production of haemoglobin globin subunits, ineffective hematopoiesis, and increased hemolysis. Thalassemia is seen as the most frequent monogenic disease in the world. The frequency has increased especially in Mediterranean countries, the Middle East, the Far East, and also in Europe and America due to migration. Carrying thalassemia is observed very frequently in Cukurova, the Mediterranean coast, and the Aegean and Marmara regions in our country.
Infections such as HBV, HCV and HIV can be observed through frequent transfusions in children with Beta-Thalassemia major. Various endocrine, cardiac, and hepatic diseases may occur depending, on excessive iron-loading. The production of free radicals associated with excessive iron-loading is increased in these patients. In recent years, the relationship between the increase in blood lipid levels and atherosclerotic diseases was shown in the performed researches. Blood lipid levels were decreased much less in children with Beta-Thalassemia major.
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