Neonatal meningitis and ventriculitis due to multi drug resistant Acinetobacter baumannii is an emerging trend in the intensive care units across the world. These patients are difficult to treat and remain a challenge. Polypeptides are one of the main stay of the treatment. But it has poor CSF penetration and hence intraventricular injection therapy is required.

 

Acinetobacter baumannii is saprophytic and ubiquitous in both the natural and hospital environment. A. baumannii forms part of the normal skin flora in about one fourth of the population. Acinetobacter have several virulence factors which enhance their pathogenicity in the debilitated individuals as the cell wall, outer membrane protein, fimbriae, polysacchride capsule, protein S layer and slime. Acinetobacter infections are uncommon and usually involve organ system with high fluid content eg. Respiratory tract, CSF, peritoneal cavity and urinary tract.